Nerve growth factor promotes human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa

• Published in: Andrologia Vol. 47; no. 9; pp. 1041 - 1046
• Main Authors: Lin, Kai, Ding, Xue-Feng, Shi, Cui-Ge, Zeng, Dan, QuZong, SuoLang, Liu, Shu-Hong, Wu, Yan, LuoBu, GeSang, Fan, Ming, Zhao, Y.-Q.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: Assisted reproduction; Fertility; Growth factors; Humans; in vitro; In Vitro Techniques; Male; Motility; nerve growth factor; Nerve Growth Factor - pharmacology; Nervous system; Sperm; sperm motility; Sperm Motility - drug effects; Spermatozoa - drug effects; sperm motility; Assisted reproduction; nerve growth factor; fertility; in vitro
• ISSN: 0303-4569; 1439-0272
• DOI: 10.1111/and.12375

Summary Nerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose‐dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.