Toxic effects of arsenic on semen and hormonal profile and their amelioration with vitamin E in Teddy goat bucks

• Published in: Andrologia Vol. 48; no. 10; pp. 1220 - 1228
• Main Authors: Zubair, M., Ahmad, M., Jamil, H., Deeba, F.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.12.2016; John Wiley & Sons, Inc
• Subjects: Animals; Arsenites - toxicity; Enzyme-Linked Immunosorbent Assay; Follicle Stimulating Hormone - blood; Goats; Hydrocortisone - blood; Luteinizing Hormone - blood; Male; Semen; Semen - drug effects; Semen Analysis; semen and hormones; sodium arsenite; Sodium Compounds - toxicity; Teddy bucks; Testis - drug effects; Testosterone - blood; Vitamin E - pharmacology; semen and hormones; sodium arsenite; Semen; Teddy bucks
• ISSN: 0303-4569; 1439-0272; 1439-0272
• DOI: 10.1111/and.12564

Summary The present environmental study has been planned to investigate the toxic effects of arsenic on reproductive functions of Teddy bucks as well as to examine whether these toxic effects are ameliorated by vitamin E. Sixteen adult Teddy bucks were divided randomly into four equal groups A, B, C and D with following treatment: A (control), B (sodium arsenite 5 mg kg−1 BW day−1), C (vit E 200 mg kg−1 BW day−1 + Arsenic 5 mg kg−1 BW day−1) and D (vit E 200 mg kg−1 BW day−1). This treatment was continued for 84 days. Semen quality parameters were evaluated weekly. Male testosterone, luteinising hormone (LH), follicle‐stimulating hormone (FSH) and cortisol levels were measured through enzyme‐linked immunosorbent assay (ELISA) after every 2 weeks. The data were subjected to two‐way analysis of variance followed by Duncan test for multiple comparisons. Semen evaluation parameters were reduced significantly (P < 0.05) in arsenic‐treated animals. The serum hormonal profile of testosterone, LH and FSH was reduced significantly (P < 0.05) in arsenic group, while the serum level of cortisol was increased. Vitamin E alleviated the toxic effects of arsenic on semen and hormonal parameters. It may be concluded from this study that sodium arsenite causes major toxicity changes in semen and hormonal profile in Teddy goat bucks and vitamin E has ameliorative effects on these toxic changes.