Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis
ABSTRACT Introduction: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder. Methods: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross‐sectional area...
Saved in:
Published in | Muscle & nerve Vol. 54; no. 6; pp. 1133 - 1135 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.12.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | ABSTRACT
Introduction: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder. Methods: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross‐sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and MRI. Results: HRUS CSA values of the median nerve in the forearm (P = 0.002) and the ulnar nerve distal to the sulcus (P = 0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60; P < 0.001). Conclusions: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. Muscle Nerve, 2016 Muscle Nerve 54: 1133–1135, 2016 |
---|---|
Bibliography: | ArticleID:MUS25391 ark:/67375/WNG-MKMLQMT4-3 istex:291F62DFB1A4B3892CC51E88E09EB09A7B75B688 Conflicts of Interest and Disclosures This study received no funding. Funding The authors report no conflicts of interest relevant to the study described. B.A. Jongbloed, J.W. Bos, Clemens Bos en W. Haakma report no disclosures. H.S. Goedee receives research support from the Prinses Beatrix Spierfonds. J. Hendrikse receives support from the Netherlands Organization for Scientific Research (NWO) under grant 91712322, the European Research Council under grant agreements 637024. L.H. van den Berg serves on scientific advisory boards for the Prinses Beatrix Spierfonds, Thierry Latran Foundation, Biogen Idec and Cytokinetics; received an educational grant from Baxter International Inc.; serves on the editorial board of Amyotrophic Lateral Sclerosis and the Journal of Neurology, Neurosurgery and Psychiatry; and receives research support from the Prinses Beatrix Spierfonds, Netherlands ALS Foundation, The European Community's Health Seventh Framework Programme (grant agreement 259867), The Netherlands Organization for Health Research and Development (Vici Scheme, JPND (SOPHIA, STRENGTH)). W.L. van der Pol receives research support from the Prinses Beatrix Spierfonds; The Netherlands ALS Foundation; Stichting Spieren voor Spieren. Drs. Van den Berg and Van der Pol contributed equally to this manuscript. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0148-639X 1097-4598 |
DOI: | 10.1002/mus.25391 |