Quantitative measurements of proton spin-lattice (T1) and spin-spin (T2) relaxation times in the mouse brain at 7.0 T

• Published in: Magnetic resonance in medicine Vol. 49; no. 3; pp. 576 - 580
• Main Authors: Guilfoyle, David N., Dyakin, Victor V., O'Shea, Jacqueline, Pell, Gaby S., Helpern, Joseph A.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.03.2003; Williams & Wilkins
• Subjects: Age Factors; Animals; Biological and medical sciences; Brain - anatomy & histology; corpus callosum; Echo-Planar Imaging - instrumentation; Echo-Planar Imaging - methods; hippocampus; Investigative techniques, diagnostic techniques (general aspects); k-space; Medical sciences; Mice; Mice, Inbred Strains; Nervous system; Phantoms, Imaging; Protons; Radiodiagnosis. Nmr imagery. Nmr spectrometry; retrosplenial granular (RSG) cortex; snapshot FLASH; Cerebral cortex; Rodentia; Central nervous system; k-space; NMR spectrometry; Nuclear magnetic resonance imaging; Corpus callosum; Relaxation time; snapshot FLASH; Vertebrata; Mammalia; Spin spin relaxation; Mouse; Animal; Measurement method; retrosplenial granular (RSG) cortex; T1; Hippocampus; T2; Brain (vertebrata); Quantitative analysis
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.10371

The goal of this work is to provide regional T1 and T2 values at a field strength of 7 T for the normal mouse brain at 6 weeks and 1 year old. A novel segmented snapshot FLASH sequence was used to measure T1 in the hippocampus, corpus callosum, and the retrosplenial granular (RSG) cortex; T2 measurements were made in the same regions using a single spin echo sequence repeated at six separate echo times. Both T1 and T2 measurements were validated with phantom measurements. Magn Reson Med 49:576–580, 2003. © 2003 Wiley‐Liss, Inc.