Reduced serum progranulin level might be associated with Parkinson's disease risk
Background and purpose Common genetic variants (rs5848 and rs646776) have been reported as regulators of blood progranulin (GRN) levels in healthy individuals. Methods To assess the influence of rs5848 and rs646776 polymorphisms in both serum GRN level and risk for common neurodegenerative diseases,...
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Published in | European journal of neurology Vol. 20; no. 12; pp. 1571 - 1573 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.12.2013
John Wiley & Sons, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background and purpose
Common genetic variants (rs5848 and rs646776) have been reported as regulators of blood progranulin (GRN) levels in healthy individuals.
Methods
To assess the influence of rs5848 and rs646776 polymorphisms in both serum GRN level and risk for common neurodegenerative diseases, we studied 304 patients with Parkinson's disease (PD), 217 individuals with Alzheimer's disease, 131 subjects with mild cognitive impairment, and 126 controls.
Results
The mean concentration of GRN in the serum of patients with PD (319.6 ng/ml) was significantly lower than that of controls (371.5 ng/ml; P = 0.009), whereas there were no significant differences between other groups. Rs646776 minor allele carriers had lower serum GRN levels in each of the four subgroups. There was no correlation between rs5848 genotypes and serum GRN concentrations. Genotype frequencies of both polymorphisms did not differ between groups.
Conclusion
Reduced circulating GRN levels might be associated with PD risk by pathogenic factors different from rs5848 and rs646776 polymorphisms. |
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Bibliography: | ArticleID:ENE12090 ark:/67375/WNG-BCMXK82D-V CIBERNED - No. CB06/07/0037 CIEN Foundation - No. PI019/09 istex:04F5BEF9E61054094725D8CF5392B33FA1A4E791 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1351-5101 1468-1331 |
DOI: | 10.1111/ene.12090 |