Quantitative analysis of cortical pyramidal neurons after corpus callosotomy

• Published in: Annals of neurology Vol. 54; no. 1; pp. 126 - 130
• Main Authors: Jacobs, Bob, Creswell, Johanna, Britt, Jonathan P., Ford, Kevin L., Bogen, Joseph E., Zaidel, Eran
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2003; Willey-Liss
• Subjects: Adolescent; Adult; Biological and medical sciences; Cell Count; Corpus Callosum - surgery; Dendrites - ultrastructure; Epilepsy, Generalized - surgery; Frontal Lobe - ultrastructure; Humans; Male; Medical sciences; Neurons - ultrastructure; Neurosurgery; Neurosurgical Procedures - methods; Postoperative Period; Pyramidal Cells - ultrastructure; Skull, brain, vascular surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Human; Nervous system diseases; Epilepsy; Ablation; Corpus callosum; Cerebral disorder; Dendrite; Surgery; Central nervous system disease; Dendritic spine; Deafferentation; Pyramidal neuron; Quantitative analysis
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.10620

This study quantitatively explored the dendritic/spine extent of supragranular pyramidal neurons across several cortical areas in two adult male subjects who had undergone a callosotomy several decades before death. In all cortical areas, there were numerous atypical, supragranular pyramidal neurons with elongated “tap root” basilar dendrites. These atypical cells could be associated with an underlying epileptic condition and/or could represent a compensatory mechanism in response to deafferentation after callosotomy. Ann Neurol 2003