Analysis of ibuprofen in serum by capillary electrophoresis

A rapid method for analysis of the analgesic drug ibuprofen in serum by capillary zone electrophoresis in a borate buffer 160 mmol/l pH 8.5 is described. The method involves deproteinization with acetonitrile to remove serum proteins followed by direct injection on the capillary. The recoveries of s...

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Bibliographic Details
Published inJournal of chromatography. B, Biomedical applications Vol. 683; no. 1; pp. 115 - 118
Main Authors Shihabi, Z.K., Hinsdale, M.E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 09.08.1996
Subjects
Anti-Inflammatory Agents, Non-Steroidal - blood
Electrophoresis, Capillary - methods
Humans
Ibuprofen
Ibuprofen - blood
Spectrophotometry, Ultraviolet
Ibuprofen
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Summary:A rapid method for analysis of the analgesic drug ibuprofen in serum by capillary zone electrophoresis in a borate buffer 160 mmol/l pH 8.5 is described. The method involves deproteinization with acetonitrile to remove serum proteins followed by direct injection on the capillary. The recoveries of standards added to the serum were 84–92%. The method is suited for analysis of samples with concentrations >10 mg/l. Many other analgesics such as ketoprofen, daypro and salicylates can also be determined by this method.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0378-4347
1572-6495
DOI:10.1016/0378-4347(96)00150-8