RNA epigenetics in pulmonary diseases: Insights into methylation modification of lncRNAs in lung cancer

• Published in: Biomedicine & pharmacotherapy Vol. 175; p. 116704
• Main Authors: Jiang, Junjie, Duan, Minghao, Wang, Zheng, Lai, Yuwei, Zhang, Chunfang, Duan, Chaojun
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2024; Elsevier
• Subjects: Animals; DNA Methylation - genetics; Epigenesis, Genetic; Epigenetics; Gene Expression Regulation, Neoplastic; Humans; LncRNA; Lung cancer; Lung Diseases - genetics; Lung Neoplasms - genetics; Lung Neoplasms - pathology; m6A; Methylation; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; ADC; TET; Ile; Lung cancer; LncRNA; RRM; SiRNA; WGCNA; 2’-O-M; Gly; TRNA; CTLA4; CeRNA; RNAPII; JUNB; CSCs; RMRP; HAVCR2; LAG3; SQC; 5’ UTR; LncRNAs; MiRNA; METTL3; Ψ; PDCD1LG2; EMT; TCGA; 3-DAA; Sec; Hm5C; RGG; CRC; M6Am; Arg; M5C; LUSC; XIST; M1A; PD-1; CD274; HuR; IL6-JAK-STAT3; M5C-LPS; Phe; LUAD; NcRNAs; LS-SCLC; TAMs; SnoRNA; PiRNAs; CCL5; CCL4; CCL3; M6A; CCL2; TGF-β; CTLA-4; TIGIT; 3’ UTR; CCL25; SCLC; JUN; SIGLEC15; NSCLC; OS; TIMER; TMB; TIME; SnRNA; TRNA Asp GTC A9; CTD; LC; Epigenetics; PDCD1; M7G; Methylation; Leu; T-loop; CCL27; m6A
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.116704

Long non-coding RNAs (lncRNAs) are pivotal controllers of gene expression through epigenetic mechanisms, Methylation, a prominent area of study in epigenetics, significantly impacts cellular processes. Various RNA base methylations, including m6A, m5C, m1A, and 2’-O-methylation, profoundly influence lncRNA folding, interactions, and stability, thereby shaping their functionality. LncRNAs and methylation significantly contribute to tumor development, especially in lung cancer. Their roles encompass cell differentiation, proliferation, the generation of cancer stem cells, and modulation of immune responses. Recent studies have suggested that dysregulation of lncRNA methylation can contribute to lung cancer development. Furthermore, methylation modifications of lncRNAs hold potential for clinical application in lung cancer. Dysregulated lncRNA methylation can promote lung cancer progression and may offer insights into potential biomarker or therapeutic target. This review summarizes the current knowledge of lncRNA methylation in lung cancer and its implications for RNA epigenetics and pulmonary diseases. [Display omitted] •Modifications such as m6A, m5C, m1A and 2’-O-M affect the folding, interaction and stability of lncRNA and further affect its function.•LncRNA and aberrant methylation can affect lung cancer cells and the tumor immune microenvironment.•The methylation modification of lncRNA plays a crucial role in clinical applications such as diagnosis, treatment and prognosis of lung cancer.