Preparation and in vitro bioactivity of hydroxyapatite/solgel glass biphasic material

• Published in: Biomaterials Vol. 23; no. 8; pp. 1865 - 1872
• Main Authors: Ragel, C.V., Vallet-Regı́, M., Rodrı́guez-Lorenzo, L.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2002
• Subjects: Bioactive solgel glasses; Calcium Compounds - chemistry; Durapatite - pharmacology; Gels - chemistry; Glass - chemistry; Hydroxyapatite; In vitro bioactivity; Kinetics; Materials Testing; Microscopy, Electron, Scanning; Oxides - chemistry; Phosphorus Compounds - chemistry; Silicon - chemistry; Silicon Dioxide - chemistry; SiO2–CaO–P2O5 system; Solgel glass/calcium phosphates biphasic materials; Spectroscopy, Fourier Transform Infrared; Temperature; Time Factors; Hydroxyapatite; Solgel glass/calcium phosphates biphasic materials; In vitro bioactivity; SiO2–CaO–P2O5 system; Bioactive solgel glasses
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/S0142-9612(01)00313-1

Hydroxyapatite/solgel glass biphasic material has been obtained in order to improve the bioactivity of the hydroxyapatite (OHAp). A mixture of stoichiometric OHAp and the precursor gel of a solgel glass, with nominal composition in mol% CaO-26, SiO2-70, P2O5-4, has been prepared. The amounts of components used have been selected to obtain a final relationship for OHAp/solgel glass of 60/40 on heating. Two different thermal treatments have been used: (i) 700°C, temperature of solgel glass stabilisation and (ii) 1000°C, lower temperature of hydroxyapatite sintering. The bioactivity of the resulting materials has been examined in vitro by immersion in simulated body fluid at 37°C. The results obtained show that both materials are bioactive. The apatite-like layer grown is greater for the new materials than for the OHAp and the solgel glass themselves.