Platelets as a source of fibroblast growth-promoting activity

• Published in: Experimental cell research Vol. 87; no. 2; pp. 297 - 301
• Main Authors: Kohler, Nancy, Lipton, A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.1974
• Subjects: Animals; Blood; Blood Platelets; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Hot Temperature; Hydrogen-Ion Concentration; Mice; Molecular Weight; Pepsin A - pharmacology; Rats; Simian virus 40; Stimulation, Chemical

Evidence is presented that platelets are an enriched source of growth-promoting activity for 3T3 cells, an established line of mouse fibroblasts. Rat or human serum stimulates 3T3 cell growth more than autologous plasma; this increased activity is at least partly due to the release of a growth-promo...