Effect of Age on Gastric Acid, Pepsin, Pepsinogen Group A and Gastrin Secretion in Peptic Ulcer Patients

To verify the effect of age on gastric secretions in gastric (GU) and duodenal ulcer (DU) patients, we carried out a retrospective study evaluating basal and stimulated gastric acid secretion in 427 peptic ulcer subjects aged between 12 and 73 years (GU = 74, DU = 353) in addition to studying gastri...

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Published inGerontology (Basel) Vol. 40; no. 5; pp. 253 - 259
Main Authors Pilotto, Alberto, Vianello, Fabio, Di Mario, Francesco, Plebani, Mario, Farinati, Fabio, Ferruccio Azzini, Carlo
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 1994
Subjects
Adolescent
Adult
Aged
Aging - physiology
Child
Clinical Section
Duodenal Ulcer - physiopathology
Female
Gastric Acid - secretion
Gastric Mucosa - drug effects
Gastric Mucosa - secretion
Gastrins - secretion
Humans
Male
Middle Aged
Pentagastrin - pharmacology
Pepsin A - secretion
Pepsinogens - secretion
Peptic Ulcer - physiopathology
Retrospective Studies
Stomach Ulcer - physiopathology
Peptic ulcer
Pepsin
Pepsinogen
Gastric acid
Gastrin
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Summary:To verify the effect of age on gastric secretions in gastric (GU) and duodenal ulcer (DU) patients, we carried out a retrospective study evaluating basal and stimulated gastric acid secretion in 427 peptic ulcer subjects aged between 12 and 73 years (GU = 74, DU = 353) in addition to studying gastric juice pepsin, serum pepsinogen group A (PGA) and gastrin in 175 patients (GU = 28, DU = 147). All subjects were then divided into groups according to their sex and age ( < 30, 30–39, 40–49, 50–59 and > 60 years). Basal, maximal and peak acid outputs (BAO, MAO, PAO) were unchanged in the various age groups, though MAO and PAO were higher in males than females and in DU than in those with GU, even in the elderly ( > 60 years). Pepsin and gastrin levels were unchanged at the various ages in GU and DU, while PGA was higher in males with DU aged 50 or over. This demonstrates that acid, pepsin and gastrin secretions do not change with age in ulcer patients. Acid secretion retains its typical distribution according to pathology (DU > GU) and sex (males > females), and also appears to have a fundamental pathogenetic role in peptic ulcer in the elderly.
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ISSN:0304-324X
1423-0003
DOI:10.1159/000213593