Apparent inosine uptake by the human heart

• Published in: Cardiovascular research Vol. 23; no. 6; pp. 484 - 488
• Main Authors: DE JONG, JAN WILLEM, CZARNECKI, WLODZIMIERZ, RUŻYLLO, WITOLD, HUIZER, TOM, HERBACZYŃSKA-CEDRO, KRYSTYNA
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.1989
• Subjects: Adult; Biological and medical sciences; Cardiac Catheterization; Cardiotonic agents; Cardiovascular system; Coronary Disease - metabolism; Coronary Disease - physiopathology; Female; Hemodynamics; human heart; Humans; Hypoxanthine; Hypoxanthines - blood; Inosine - blood; Inosine - pharmacokinetics; inosine infusion; inotropy; Male; Medical sciences; Middle Aged; Myocardium - metabolism; nucleotide regeneration; Pharmacology. Drug treatments; Xanthine; Xanthines - blood; Heart; Human; Cardiotonic agent; Intravenous administration; Contractility; Inosine; Hemodynamics; Biological activity
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1093/cvr/23.6.484

Although inosine has been used clinically to support the myocardium, no data are available on the fate of exogenous inosine in the human heart. We therefore infused six patients, catheterised for coronary angiography, with inosine (5 mg·kg−1·min−1 intravenously) for 6 minutes. Before infusion, the arterio-venous difference of inosine, hypoxanthine and xanthine across the heart was nil. During infusion, arterial inosine increased substantially, exceeding the coronary sinus concentration by a maximum of 200 (SEM 53) μmol·litre−1, p = 0.02, at the fourth minute. Arterial hypoxanthine and xanthine also increased, while the arterio-venous difference became 16(11) and 10(3) (p = 0.04) μmol·litre−1, respectively. Left ventricular dP/dtmax increased by 22(7)% (p = 0.04) at the end of infusion. Thus, there seemed to be substantial uptake of inosine by the human heart, followed by improvement in haemodynamics.