The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure
Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as...
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Published in | Bioscience reports Vol. 38; no. 5 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Portland Press Ltd
31.10.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as promising diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work |
ISSN: | 0144-8463 1573-4935 |
DOI: | 10.1042/BSR20180542 |