The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure

Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as...

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Bibliographic Details
Published inBioscience reports Vol. 38; no. 5
Main Authors Li, Hui-Zi, Lin, Zhong, Xu, Xiang-He, Lin, Nan, Lu, Hua-Ding
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 31.10.2018
Subjects
Aged
Alternative Splicing
Biomarkers - blood
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Computational Biology - methods
Disease Progression
Exons
Gene Expression Profiling
Gene Expression Regulation
Humans
Introns
MicroRNAs - genetics
MicroRNAs - metabolism
Osteoarthritis - blood
Osteoarthritis - diagnosis
Osteoarthritis - genetics
Osteoarthritis - pathology
Review
RNA - blood
RNA - genetics
RNA Precursors - genetics
RNA Precursors - metabolism
CircRNA
Osteoarthritis
biogenesis
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Summary:Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression of OA. These findings suggested that circRNAs may act as promising diagnostic biomarkers and therapeutic targets for OA. In this review, we summarize the biogenesis and biological functions of circRNAs and explore the underlying roles of circRNAs in OA, which may enlighten further studies and contribute to the early diagnosis and intervention of OA.
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These authors contributed equally to this work
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20180542