Enhanced Anti-Skin-Aging Activity of Yeast Extract-Treated Resveratrol Rice DJ526

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 6; p. 1951
• Main Authors: Kantayos, Vipada, Kim, Jin-Suk, Baek, So-Hyeon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.03.2022; MDPI
• Subjects: Aging; anti-inflammation; antioxidant; Antioxidants; Antioxidants - pharmacology; Collagen; Cytokines; elicitor; Gene expression; Inflammation; Jasmonic acid; Melanin; melanogenesis; Methyl jasmonate; Oryza; Oxidative stress; Plants; Protein expression; Resveratrol; Resveratrol - pharmacology; Rice; Seeds; Skin; Skin Aging; Transcription factors; Tumor necrosis factor-α; Wound healing; Yeast; Yeasts; melanogenesis; antioxidant; wound healing; anti-inflammation; resveratrol; elicitor
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27061951

Resveratrol is a powerful antioxidant that defends against oxidative stress in cells but is not found in large quantities in plants. Resveratrol-enriched rice DJ526, which was developed as a functional crop, shows a diverse range of biological activities. Resveratrol production is measured as total resveratrol and its glycoside, piceid, which is mainly found in plant-derived resveratrol. In the present study, elicitation using yeast extract (YE), methyl jasmonate, and jasmonic acid increased resveratrol production in DJ526 rice seeds. DJ526 seeds elicited using 1 g/L (YE1) and 5 g/L yeast extract (YE5) showed enhanced resveratrol production and antioxidant activity. YE5-treated DJ526 seeds showed decreased melanin content by 46.1% and 37.0% compared with the negative control and DJ526 (non-elicitation), respectively. Both YE1 and YE5 efficiently improved the wound-healing activity by reducing the wound gap faster than in untreated cells, with a maximum rate of 60.2% at 24 h and complete closure at 48 h. YE1 and YE5 significantly decreased the levels of proinflammatory cytokine, TNF-α, and enhanced collagen synthesis in inflammatory cells. These findings indicate that YE-treated resveratrol rice DJ526 may improve resveratrol production and could be an active antiaging ingredient for cosmetic and skin therapy applications.