Macrophage-Activating Cytokines in Human Immununodeficiency Virus Type 1–Infected and –Uninfected Patients with Pulmonary Tuberculosis

• Published in: The Journal of infectious diseases Vol. 183; no. 12; pp. 1805 - 1809
• Main Authors: Mayanja-Kizza, Harriet, Johnson, John L., Hirsch, Christina S., Peters, Pierre, Surewicz, Krystyna, Wu, Mianda, Nalugwa, Gladys, Mubiru, Francis, Luzze, Henry, Wajja, Anne, Aung, Htin, Ellner, Jerrold J., Whalen, Christopher, Toossi, Zahra
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.06.2001; University of Chicago Press; Oxford University Press
• Subjects: Adult; AIDS-Related Opportunistic Infections - microbiology; Bacterial diseases; Biological and medical sciences; CD4 Lymphocyte Count; Concise Communications; Cytokines; HIV 1; HIV Infections - complications; HIV Infections - immunology; Human bacterial diseases; Human immunodeficiency virus 1; Human viral diseases; Humans; Infections; Infectious diseases; Interferon-gamma - biosynthesis; Interferons; Leukocytes, Mononuclear - immunology; Macrophage Activation; Medical sciences; Messenger RNA; Middle Aged; Mycobacterium tuberculosis; Nitric Oxide - biosynthesis; Pulmonary tuberculosis; Radiography, Thoracic; Sputum; Sputum - microbiology; Tuberculosis; Tuberculosis and atypical mycobacterial infections; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - immunology; Tumor Necrosis Factor-alpha - biosynthesis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses; Immunopathology; Lung disease; Opportunistic infection; HIV-1 virus; Respiratory disease; Cytokine; Retroviridae; AIDS; Lentivirus; Immune deficiency; Blood; Necrosis; Infection; Virus; Blood cell; Tumor necrosis factor; Viral disease; Tumor; Human immunodeficiency virus; Infected cell; Tumor necrosis factor α; Gamma interferon; Macrophage
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/320725

Tuberculosis (TB) is the most common opportunistic infection in human immunodeficiency virus type 1 (HIV-1)–infected patients globally and occurs throughout the course of HIV-1 disease. Here the production of interferon (IFN)–γ and tumor necrosis factor (TNF)–α by peripheral blood mononuclear cells (PBMC) of HIV-1–infected versus –uninfected patients with newly diagnosed pulmonary TB (PTB) was compared. Findings were correlated with cytokine profiles, clinical presentation, and expression of inducible nitric oxide (iNOS). Most HIV-1/PTB patients with a CD4 cell count of 200–500 cells/μL had high IFN-γ production and radiographic evidence of atypical PTB. Low IFN-γ production and radiographic evidence of reactivated PTB characterized both HIV-1/PTB patients with a CD4 cell count ⩾500 cells/μL and HIV-1–uninfected patients. TNF-α levels were similar in all HIV-1/PTB patients, regardless of CD4 cell count. Induction of iNOS in PBMC was low and was associated with low IFN-γ production. These data underscore the potential pathogenic role of macrophage-activating cytokines in TB in HIV-1–infected patients