Natural products modulate phthalate-associated miRNAs and targets

• Published in: Ecotoxicology and environmental safety Vol. 284; p. 117015
• Main Authors: Chuang, Ya-Ting, Yen, Ching-Yu, Chien, Tsu-Ming, Chang, Fang-Rong, Wu, Kuo-Chuan, Tsai, Yi-Hong, Shiau, Jun-Ping, Chang, Hsueh-Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2024; Elsevier
• Subjects: Cancer; MiRNAs; Natural products; Phthalates; Protection; Targets; MiRNAs; Targets; Natural products; Protection; Phthalates; Cancer
• ISSN: 0147-6513; 1090-2414; 1090-2414
• DOI: 10.1016/j.ecoenv.2024.117015

Phthalates are widespread and commonly used plasticizers that lead to adverse health effects. Several natural products provide a protective effect against phthalates. Moreover, microRNAs (miRNAs) are regulated by natural products and phthalates. Therefore, miRNAs' impacts and potential targets may underlie the mechanism of phthalates. However, the relationship between phthalate-modulated miRNAs and phthalate protectors derived from natural products is poorly understood and requires further supporting information. In this paper, we review the adverse effects and potential targets of phthalates on reproductive systems as well as cancer and non-cancer responses. Information on natural products that attenuate the adverse effects of phthalates is retrieved through a search of Google Scholar and the miRDB database. Moreover, information on miRNAs that are upregulated or downregulated in response to phthalates is collected, along with their potential targets. The interplay between phthalate-modulated miRNAs and natural products is established. Overall, this review proposes a straightforward pathway showing how phthalates modulate different miRNAs and targets and cause adverse effects, which are partly attenuated by several natural products, thereby providing a direction for investigating the natural product–miRNA–target axis against phthalate-induced effects. •miRNAs are regulated by natural products and phthalates.•Several natural products protecting against phthalates are retrieved.•The adverse effects and potential targets of phthalates are retrieved.•The interplay between phthalate-modulated miRNAs and natural products is established.•We explore the natural product–miRNA–target axis against phthalate-induced effects.