Abnormal neural precursor cell regulation in the early postnatal Fragile X mouse hippocampus

Highlights • Aberrant in vitro regulation of Fmr1- KO neural precursor cells. • Proliferation of hippocampal NPCs is decreased in early postnatal Fmr1- KO brains. • Smaller proportion of NSCs and higher proportion of neuroblasts in the P7 Fmr1- KO DG.

Saved in:
Bibliographic Details
Published inBrain research Vol. 1666; pp. 58 - 69
Main Authors Sourial, Mary, Doering, Laurie C
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2017
Subjects
Animals
Cell cycle
Cell Differentiation - physiology
Dentate Gyrus - metabolism
Fmr1-knockout mice
Fragile X Mental Retardation Protein - genetics
Fragile X Mental Retardation Protein - metabolism
Fragile X syndrome
Fragile X Syndrome - metabolism
Hippocampus - metabolism
Mice, Knockout
Neural stem cells
Neural Stem Cells - cytology
Neurogenesis - physiology
Neurology
Neurons - cytology
Neurospheres
Neural stem cells
Fmr1-knockout mice
Fragile X Syndrome
Neurospheres
Cell cycle
Fragile X syndrome
Online AccessGet full text

Cover

More Information
Summary:Highlights • Aberrant in vitro regulation of Fmr1- KO neural precursor cells. • Proliferation of hippocampal NPCs is decreased in early postnatal Fmr1- KO brains. • Smaller proportion of NSCs and higher proportion of neuroblasts in the P7 Fmr1- KO DG.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.04.013