Review on intrauterine programming: Consequences in rodent models of mild diabetes and mild fat overfeeding are not mild

• Published in: Placenta (Eastbourne) Vol. 52; pp. 21 - 32
• Main Authors: Jawerbaum, A, White, V
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2017
• Subjects: Animals; Diabetes and pregnancy; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Disease Models, Animal; Fat; Female; Fetal Development - physiology; Fetus; Internal Medicine; Intrauterine programming; Obstetrics and Gynecology; Offspring; Overfeeding; Placenta; Placenta - metabolism; Placenta - pathology; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Prenatal Exposure Delayed Effects - pathology; Rodentia; Offspring; Diabetes and pregnancy; Placenta; Overfeeding; Fat; Fetus; Intrauterine programming
• ISSN: 0143-4004; 1532-3102
• DOI: 10.1016/j.placenta.2017.02.009

Abstract An adverse intrauterine programming occurs in diabetes and obesity as the consequence of an adverse maternal environment that affects the appropriate fetoplacental development and growth. Experimental models of diabetes and fat overfeeding have provided relevant tools to address putative mechanisms of the adverse intrauterine programming. The current knowledge far extends from the original thoughts of the resulting intrauterine programming of metabolic and cardiovascular diseases to a full range of alterations that affect multiple tissues, organs, and systems that will compromise the long-life health of the offspring. This review examines the postnatal effects of rodent models of mild diabetes and fat overfeeding, identifying the multiple organ derangements in the offspring resulting from mild maternal adverse conditions. In addition, the comparison of experimental models of severe diabetes and fat overfeeding and the crucial role of the placenta are discussed, providing an update of the actual scenario of the putative mechanisms and adverse consequences of maternal metabolic derangements.