Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure

• Published in: Neural regeneration research Vol. 8; no. 27; pp. 2566 - 2572
• Main Authors: Wang, Yinxu, Wang, Xiaoming, Ke, Sha, Tan, Juan, Hu, Litian, Zhang, Yaodan, Cui, Wenjuan
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 25.09.2013; Medknow Publications & Media Pvt. Ltd; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: Animal experimentation; Chaos theory; Convulsions & seizures; Electroencephalography; Epilepsy; Fecal incontinence; Health aspects; Magnetic instruments; Prevention; Research and Report : Neurodegenerative Disease and Neural Regeneration; SD大鼠; Transcranial magnetic stimulation; 仿真; 低频; 慢性; 抗癫痫作用; 磁模拟; 腹腔注射; 非线性动态; epilepsy; grant-supported paper; neural regeneration; nonlinear analysis; neuroregeneration; nonlinear parameters; epileptic discharge; epileptic seizure; electroencephalogram; repetitive transcranial magnetic stimulation
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2013.27.008

Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alographic parameters in rats with chronic epilepsy and explored the mechanism underlying repeti-tive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was estab-lished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear elec-electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.