Characterization of the mouse JAB1 cDNA and protein

JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcrip...

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Published inGene Vol. 242; no. 1; pp. 41 - 50
Main Authors Bounpheng, Mangkey A., Melnikova, Irena N., Dodds, Sherry G., Chen, Heping, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Christy, Barbara A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 25.01.2000
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Abstract JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcription factors, while the COP9 complex is involved in repression of photomorphogenesis in Arabidopsis. In this study, we describe the partial characterization of mouse JAB1 (mJAB1). The murine JAB1 protein is encoded by a gene located on mouse chromosome 1. mJAB1 mRNA is abundantly expressed in a variety of adult tissues as well as in mouse embryos. The JAB1 protein was readily detectable in many cell types and localized to both the nucleus and cytoplasm. Endogenous JAB1 protein is relatively stable and its degradation is not perturbed by blocking 26S proteasome activity, suggesting that this protein is not degraded by the ubiquitin-mediated proteolytic pathway.
AbstractList JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcription factors, while the COP9 complex is involved in repression of photomorphogenesis in Arabidopsis. In this study, we describe the partial characterization of mouse JAB1 (mJAB1). The murine JAB1 protein is encoded by a gene located on mouse chromosome 1. mJAB1 mRNA is abundantly expressed in a variety of adult tissues as well as in mouse embryos. The JAB1 protein was readily detectable in many cell types and localized to both the nucleus and cytoplasm. Endogenous JAB1 protein is relatively stable and its degradation is not perturbed by blocking 26S proteasome activity, suggesting that this protein is not degraded by the ubiquitin-mediated proteolytic pathway.
JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcription factors, while the COP9 complex is involved in repression of photomorphogenesis in Arabidopsis. In this study, we describe the partial characterization of mouse JAB1 (mJAB1). The murine JAB1 protein is encoded by a gene located on mouse chromosome 1. mJAB1 mRNA is abundantly expressed in a variety of adult tissues as well as in mouse embryos. The JAB1 protein was readily detectable in many cell types and localized to both the nucleus and cytoplasm. Endogenous JAB1 protein is relatively stable and its degradation is not perturbed by blocking 26S proteasome activity, suggesting that this protein is not degraded by the ubiquitin-mediated proteolytic pathway.
Author Gilbert, Debra J.
Dodds, Sherry G.
Jenkins, Nancy A.
Chen, Heping
Bounpheng, Mangkey A.
Copeland, Neal G.
Christy, Barbara A.
Melnikova, Irena N.
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  givenname: Irena N.
  surname: Melnikova
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  givenname: Barbara A.
  surname: Christy
  fullname: Christy, Barbara A.
  email: christy@uthscsa.edu
  organization: Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78245-3207, USA
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Issue 1
Keywords Ubiquitin
AJH, Arabidopsis JAB1 homologue
MAP kinase, mitogen activated protein kinase
FBS, fetal bovine serum
mRNA
DMEM, Dulbecco's minimal essential medium
SDS, sodium dodecyl sulfate
DAPI, 4,6–Diamidino–2–phenylindole
HLH, helix–loop–helix
SAPK/JNK, stree activated protein kinase/Jun N-terminal kinase
RFLP, restriction fragment length polymorphism
Subcellular location
Chromosomal location
Protein expression
PCR, polymerase chain reaction
PAGE, polyacrylimide gel electrophoresis
mJAB1, murine Jun activation domain binding protein 1
Proteasome
Language English
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Snippet JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex,...
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SubjectTerms Animals
c-Jun gene
c-Jun protein
Cell Line
Cell Nucleus - chemistry
Chromosomal location
chromosome 1
Chromosome Mapping
COP9 Signalosome Complex
Cytoplasm - chemistry
DNA, Complementary - chemistry
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Embryo, Mammalian - metabolism
Female
Fluorescent Antibody Technique
Gene Expression Regulation
Gene Expression Regulation, Developmental
Humans
Hydrolysis
Intracellular Signaling Peptides and Proteins
JAB1 protein
JunD gene
JunD protein
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
mRNA
Muridae
Oligopeptides
Peptide Hydrolases - metabolism
Peptides - genetics
Proteasome
Proteasome Endopeptidase Complex
Protein expression
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
RNA - genetics
RNA - metabolism
Sequence Analysis, DNA
Subcellular location
Tissue Distribution
Transcription Factors - genetics
Transcription Factors - metabolism
Ubiquitin
Ubiquitins - metabolism
Title Characterization of the mouse JAB1 cDNA and protein
URI https://dx.doi.org/10.1016/S0378-1119(99)00525-9
https://www.ncbi.nlm.nih.gov/pubmed/10721695
https://search.proquest.com/docview/17494581
https://search.proquest.com/docview/17617582
https://search.proquest.com/docview/70972152
Volume 242
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