Isolation and characterization of a new metabolite of phylloquinone in the rat

The metabolism of radioactive phylloquinone was studied in rats given warfarin. In the presence of warfarin, a new metabolite of vitamin K accumulated in liver. This compound was isolated and characterized as phylloquinone oxide, a substance which has the activity of vitamin K. 6 h after the adminis...

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Published inBiochimica et biophysica acta Vol. 201; no. 2; pp. 309 - 315
Main Authors Matschiner, John T., Bell, Robert G., Amelotti, Josephine M., Knauer, Thomas E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 24.02.1970
Subjects
Animals
Carbon Isotopes
Chromatography, Thin Layer
Liver - metabolism
Male
Myocardium - metabolism
Rats
Spectrophotometry
Spectrum Analysis
Tritium
Ultraviolet Rays
Vitamin K - metabolism
Vitamin K 1 - metabolism
Warfarin - pharmacology
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Summary:The metabolism of radioactive phylloquinone was studied in rats given warfarin. In the presence of warfarin, a new metabolite of vitamin K accumulated in liver. This compound was isolated and characterized as phylloquinone oxide, a substance which has the activity of vitamin K. 6 h after the administration [ phytyl- 14C]phylloquinone (uniformly 14C-labeled in the phytyl moiety), more than 50% of the radioactivity normally found as phylloquinone, was recovered as the oxide if the rats were given the anticoagulant drug. Evidence was obtained that liver and heart of rats fed radioactive vitamin K without warfarin contained a small percentage of the oxide.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/0304-4165(70)90305-3