Prognostic Impact of Central Sleep Apnea in Patients With Heart Failure

• Published in: Journal of cardiac failure Vol. 21; no. 2; pp. 126 - 133
• Main Authors: Grimm, Wolfram, MD, Sosnovskaya, Antonina, MD, Timmesfeld, Nina, PhD, Hildebrandt, Olaf, MSc, Koehler, Ulrich, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2015
• Subjects: Adult; Aged; Cardiovascular; Central sleep apnea; Female; Follow-Up Studies; heart failure; Heart Failure - diagnosis; Heart Failure - mortality; Heart Failure - physiopathology; Humans; Male; Middle Aged; polysomnography; Polysomnography - mortality; Polysomnography - trends; Prognosis; Prospective Studies; Sleep Apnea, Central - diagnosis; Sleep Apnea, Central - mortality; Sleep Apnea, Central - physiopathology; Survival Rate - trends; transplant-free survival; heart failure; Central sleep apnea; polysomnography; transplant-free survival
• ISSN: 1071-9164; 1532-8414
• DOI: 10.1016/j.cardfail.2014.10.017

Abstract Background Central sleep apnea (CSA) is common in patients with heart failure (HF). Earlier studies investigating the influence of CSA on mortality in HF patients, however, have yielded contradictory results. Methods and Results In a prospective study involving 267 patients with left ventricular (LV) ejection fractions ≤50%, we performed polysomnography and compared heart transplant–free survival rates between patients with no or mild CSA (apnea-hypopnea index [AHI] ≤15/h) and those with moderate CSA (AHI 15.1–30/h) or severe CSA (AHI >30/h). During 43 ± 18 months' mean follow-up, 67 patients (25%) died and 4 patients (1%) underwent heart transplantation. Multivariate Cox analysis identified age, male sex, chronic kidney disease, and decreased LV ejection fraction, but not moderate CSA or severe CSA, as predictors of transplant-free survival. Conclusions In patients with stable HF, moderate CSA as well as severe CSA do not appear to predict transplant-free survival independently from confounding factors.