Kahiricosides II–V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus

• Published in: Phytochemistry (Oxford) Vol. 65; no. 21; pp. 2909 - 2913
• Main Authors: Radwan, Mohamed M., El-Sebakhy, Nadia A., Asaad, Aya M., Toaima, Soad M., Kingston, David G.I.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.11.2004; Elsevier
• Subjects: A2780 ovarian cancer cell line; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - isolation & purification; Astragalus; Astragalus kahiricus; Astragalus Plant - chemistry; Biochemistry & Molecular Biology; Biological and medical sciences; Cell Line, Tumor; cell lines; Chemical constitution; chemical structure; chemotaxonomy; cycloartane glycoside; Cycloartane-type saponins; Cytotoxic activity; cytotoxicity; Egypt; Fabaceae; Female; Fundamental and applied biological sciences. Psychology; General pharmacology; glucopyranoside; glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; human health; Humans; kahiricosides; Leguminosae; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; Plant Components, Aerial - chemistry; plant extracts; Plant physiology and development; Plant Sciences; saponins; Science & Technology; spectral analysis; Triterpenes - isolation & purification; Egypt; Astragalus kahiricus; A2780 ovarian cancer cell line; Leguminosae; Cycloartane-type saponins; Astragalus; Cytotoxic activity; TOMENTOSUS; MODULATORS; PART; cytotoxic activity; cycloartane-type saponins; OLEANANE SAPONINS; LYMPHOCYTE-PROLIFERATION; TRITERPENE GLYCOSIDES; Antineoplastic agent; Bioassay; Molecular structure; Pharmacognosy; Biological activity; Medicinal plant; Saponin; Ovary; Cell line; Dicotyledones; Angiospermae; Plant origin; Isolation; Above ground plant part; Spermatophyta; Glycoside
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2004.08.037

Four cycloartane-type saponins, kahiricosides II–V ( 1– 4), were isolated from an Egyptian collection of the aerial parts of Astragalus kahiricus. All compounds were weakly cytotoxic to the A2780 ovarian cancer cell line. Four cycloartane-type saponins, kahiricosides II–V ( 1–4), were isolated from the aerial parts of Astragalus kahiricus of Egyptian origin. Their structures were established as 9β,19-cyclolanost-24 E-ene-3β,6α,16β,27-tetraol-3- O-β- d-glucopyranoside, 9β,19-cyclolanost-24 E-ene-3β,6α,16β,27-tetraol-3- O-(2′- O-acetyl)-β- d-glucopyranoside, 9β,19-cyclolanost-24 E-ene-3β,6α,16β,27-tetraol-3- O-(6′- O-acetyl)-β- d-glucopyranoside, and 9β,19-cyclolanost-24 E-ene-3β,6α,16β,27-tetraol-3- O-β- d-glucopyranosyl-27- O-β- d-glucopyranoside based on chemical and spectral evidences. All compounds exhibited very weak cytotoxicity against the A2780 ovarian cancer cell line.