Immunomodulatory and antitumor activities of a polysaccharide-peptide complex from a mycelial culture of Tricholoma sp., a local edible mushroom

• Published in: Life sciences (1973) Vol. 57; no. 3; pp. 269 - 281
• Main Authors: Wang, H.X, Liu, W.K, Ng, T.B, Ooi, V.E.C, Chang, S.T
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 1995
• Subjects: Adjuvants, Immunologic - isolation & purification; Adjuvants, Immunologic - pharmacology; Animals; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; antitumor activity; Basidiomycota - chemistry; Cell Division - drug effects; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; immunomodulation; macrophage; Macrophage Activation - drug effects; Male; Mice; Mice, Inbred Strains; Mitogens - pharmacology; mushroom; Nitrites - metabolism; Peptides - pharmacology; polysaccharide; Polysaccharides - pharmacology; T-Lymphocytes - drug effects; Tricholoma sp; immunomodulation; macrophage; Tricholoma sp; polysaccharide; antitumor activity; mushroom
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/0024-3205(95)00270-G

A polysaccharide-peptide complex (PSPC) with immunomodulatory and antitumor activities was obtained from a submerged mycelial culture of Tricholoma sp., a local edible mushroom. The polysaccharide-peptide complex exhibited a molecular weight of 17 K in gel filtration and a single band after SDS-polyacrylamide gel electrophoresis. It was characterized by non-adsorption on both DEAE-Sepharose CL-6B and CM-cellulose. It could activate the macrophages, stimulate the proliferation of T-cells, and inhibit the growth of sarcoma 180 in mice. It possessed more potent immunomodulatory and antitumor activities than Coriolus versicolor polysaccharopeptide (PSP) and deserves to be studied as a potential agent for immunomodulation and cancer therapy.