New insights into the interplay between autophagy, gut microbiota and insulin resistance in metabolic syndrome

• Published in: Biomedicine & pharmacotherapy Vol. 176; p. 116807
• Main Authors: Zhao, Jinyue, Duan, Liyun, Li, Jiarui, Yao, Chensi, Wang, Guoqiang, Mi, Jia, Yu, Yongjiang, Ding, Lu, Zhao, Yunyun, Yan, Guanchi, Li, Jing, Zhao, Zhixuan, Wang, Xiuge, Li, Min
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.07.2024; Elsevier
• Subjects: Autophagy; Chronic inflammation; Gut microbiota; Insulin resistance; Intestinal homeostasis; Metabolic Syndrome; Gut microbiota; Insulin resistance; Intestinal homeostasis; Chronic inflammation; Autophagy; Metabolic Syndrome
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.116807

Metabolic syndrome (MetS) is a widespread and multifactorial disorder, and the study of its pathogenesis and treatment remains challenging. Autophagy, an intracellular degradation system that maintains cellular renewal and homeostasis, is essential for maintaining antimicrobial defense, preserving epithelial barrier integrity, promoting mucosal immune response, maintaining intestinal homeostasis, and regulating gut microbiota and microbial metabolites. Dysfunctional autophagy is implicated in the pathological mechanisms of MetS, involving insulin resistance (IR), chronic inflammation, oxidative stress, and endoplasmic reticulum (ER) stress, with IR being a predominant feature. The study of autophagy represents a valuable field of research with significant clinical implications for identifying autophagy-related signals, pathways, mechanisms, and treatment options for MetS. Given the multifactorial etiology and various potential risk factors, it is imperative to explore the interplay between autophagy and gut microbiota in MetS more thoroughly. This will facilitate the elucidation of new mechanisms underlying the crosstalk among autophagy, gut microbiota, and MetS, thereby providing new insights into the diagnosis and treatment of MetS. [Display omitted] •Autophagy is intricately linked to intestinal homeostasis, gut microbiota, and microbial metabolites.•Dysfunctional autophagy is implicated in MetS, involving IR, chronic inflammation, oxidative stress, and ER stress.•A deeper insight of the crosstalk mechanism among autophagy, gut microbiota, and MetS is necessary.