Expression and Prognostic Value of ZNRD1 in Esophageal Squamous Cell Carcinoma

• Published in: Digestive diseases and sciences Vol. 54; no. 3; pp. 586 - 592
• Main Authors: Zhao, Yunping, Hong, Liu, Wang, Ruwen, Fan, Daiming
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.03.2009; Springer US; Springer; Springer Nature B.V
• Subjects: Aged; Biochemistry; Biological and medical sciences; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; China - epidemiology; DNA-Binding Proteins - metabolism; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophagus; Esophagus - metabolism; Esophagus - pathology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Reverse Transcriptase Polymerase Chain Reaction; Transplant Surgery; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; China; Zinc ribbon motif; Esophageal cancer; ZNRD1; Esophageal disease; Esophagus squamous cell carcinoma; Metabolic diseases; Malignant tumor; Esophagus cancer; Zinc; Gastroenterology; Predictive value; Digestive diseases; Cancer
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-008-0380-1

The expression of ZNRD1 in esophageal cancer was first investigated by immunohistochemical analysis, RT-PCR and real-time PCR. The ZNRD1 antibody produced a consistently cytoplasmic staining pattern in all epithelial cells. The expression of ZNRD1 was statistically correlated with differentiation, depth of invasion, lymph node metastasis, pathological stage, lymphatic invasion, and vascular invasion. The survival rates of patients with ZNRD1-negative tumors tended to be statistically lower than those with ZNRD1-positive tumors. ZNRD1 expression was also confirmed to be down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues. The results showed that ZNRD1 might play an important role in esophageal carcinogenesis.