Concomitant gentamicin-induced nephrotoxicity and bilateral ototoxicity

Co-occurrence of aminoglycoside-induced ototoxicity and nephrotoxicity is rare, possibly as a result of divergent mechanisms of tissue damage despite similarities in the anatomy of the inner ear and the proximal renal tubular epithelium. We present the case of a 63-year-old hypertensive woman who de...

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Bibliographic Details
Published inNigerian journal of clinical practice Vol. 19; no. 4; pp. 563 - 566
Main Authors Akinbodewa, A, Okunola, O
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow Publications 01.07.2016
Medknow Publications and Media Pvt. Ltd
Subjects
Gentamicins
Hearing disorders
Kidney diseases
Risk factors
gentamicin
co-occurrence
aminoglycosides
nephrotoxicity
ototoxicity
Acute kidney injury
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Summary:Co-occurrence of aminoglycoside-induced ototoxicity and nephrotoxicity is rare, possibly as a result of divergent mechanisms of tissue damage despite similarities in the anatomy of the inner ear and the proximal renal tubular epithelium. We present the case of a 63-year-old hypertensive woman who developed nonoliguric acute exacerbation of chronic renal failure and sudden onset of sensorineural deafness after receiving daily injections of gentamicin. Coexisting ototoxicity and nephrotoxicity from aminoglycosides can occur, though rare. Adverse effects of aminoglycosides are better prevented by a careful exercise of discretion by prescribers.
ISSN:1119-3077
DOI:10.4103/1119-3077.183312