Raised serum sialic acid concentration precedes onset of microalbuminuria in IDDM. A 10-year follow-up study

• Published in: Diabetes care Vol. 19; no. 5; pp. 435 - 440
• Main Authors: YOKOYAMA, H, JENSEN, J. S, MYRUP, B, MATHIESEN, E. R, RØNN, B, DECKERT, T
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.1996
• Subjects: Adult; Albuminuria - epidemiology; Associated diseases and complications; Biological and medical sciences; Biomarkers - blood; Blood Pressure; Cholesterol - blood; Cholesterol, HDL - blood; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - urine; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - blood; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - urine; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Follow-Up Studies; Glycated Hemoglobin A - analysis; Humans; Male; Medical sciences; N-Acetylneuraminic Acid; Predictive Value of Tests; Risk Assessment; Sialic Acids - blood; Time Factors; von Willebrand Factor - analysis; Endocrinopathy; Human; Immunopathology; Sialic acid; Urinary system disease; Biochemical analysis; Albumin; Biological marker; Autoimmune disease; Renal disease; Early stage; Nephropathy; Clinical biology; Insulin dependent diabetes; Serum; Diagnosis; Microalbuminuria; Proteinuria
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.19.5.435

Raised serum sialic acid concentration precedes onset of microalbuminuria in IDDM. A 10-year follow-up study. H Yokoyama , J S Jensen , B Myrup , E R Mathiesen , B Rønn and T Deckert Steno Diabetes Center, Gentofte, Denmark. Abstract OBJECTIVE--Elevated concentrations of serum sialic acid, a potent cardiovascular risk factor in the general population, have been found in patients with IDDM and microalbuminuria. We investigated whether a coincidence exists between the increase of sialic acid concentrations and albuminuria in the transition from normoalbuminuria to microalbuminuria. Furthermore, the predictability of increased sialic acid as well as von Willebrand factor (vWF) and total and HDL cholesterol concentrations in development of persistent microalbuminuria in IDDM was investigated. RESEARCH DESIGN AND METHODS--This 10-year prospective study was carried out in a cohort of 209 IDDM patients with normoalbuminuria at baseline. RESULTS--Of the cohort, 198 patients completed the follow-up period and 27 developed persistent microalbuminuria (urinary albumin excretion rate [UAER] > or = 30 mg/24 h). A coincident increase of UAER and serum sialic acid concentration was seen before persistent microalbuminuria was diagnosed. Elevation of serum sialic acid concentrations in those who later developed microalbuminuria occurred 3 years before the diagnosis of persistent microalbuminuria. Baseline serum sialic acid concentrations were significantly higher in the group of patients who later developed microalbuminuria than in the group who remained normoalbuminuric (2.02 +/- 0.41 vs. 1.85 +/- 0.31 mmol/l [means +/- SD], P < 0.05). Baseline serum sialic acid concentration correlated significantly with HbA1c, UAER, blood pressure, total cholesterol, HDL cholesterol, and vWF and was significantly predictive for development of microalbuminuria (hazards ratio [95% CI], 3.1 [1.2-8.1]; P = 0.02) after adjustments for sex, duration of diabetes, smoking, blood pressure, vWF, total cholesterol, and HDL cholesterol. Adjustment for the effects of HbA1c and UAER, however, canceled out the predictive effect of serum sialic acid. CONCLUSIONS: UAER and serum sialic acid concentration increase coincidentally before the onset of persistent microalbuminuria. An increased serum sialic acid concentration is predictive for the onset of microalbuminuria independent of age, sex, diabetes duration, smoking, blood pressure, vWF, and total HDL cholesterol.