An integrated, multidisciplinary approach for drug safety assessment

A comprehensive approach in drug safety assessment is described, with which human drug toxicity is evaluated based on the multiple disciplines of pharmacology, chemistry, drug metabolism and toxicology. Mechanistic understanding of drug toxicity and the determination of potential risk factors are pr...

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Bibliographic Details
Published inDrug discovery today Vol. 9; no. 16; pp. 687 - 693
Main Author Li, Albert P.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.08.2004
Subjects
Clinical Trials as Topic
Drug Industry
drug safety
Drug-Related Side Effects and Adverse Reactions
Humans
Interdisciplinary Communication
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Pharmacokinetics
Pharmacology
Risk Factors
Toxicity Tests
toxophore
pharmacokinetics
Toxicology
Pharmacology
Drug Discovery
toxophore
drug safety
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Summary:A comprehensive approach in drug safety assessment is described, with which human drug toxicity is evaluated based on the multiple disciplines of pharmacology, chemistry, drug metabolism and toxicology. Mechanistic understanding of drug toxicity and the determination of potential risk factors are proposed to be key parameters for an accurate prediction of human drug toxicity.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(04)03166-6