Effect of dietary cholesterol in normolipidemic subjects is not modified by nature and amount of dietary fat

• Published in: The American journal of clinical nutrition Vol. 50; no. 3; pp. 528 - 532
• Main Authors: Kestin, M, Clifton, P M, Rouse, I L, Nestel, P J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.09.1989; American Society for Clinical Nutrition
• Subjects: Apolipoproteins - blood; Biological and medical sciences; CHOLESTEROL; Cholesterol, Dietary - pharmacology; COLESTEROL; CONTENIDO DE LIPIDOS; CORPS GRAS; Diet; DIETA; Dietary Fats - administration & dosage; EXPERIMENTATION; EXPERIMENTOS; Fundamental and applied biological sciences. Psychology; GRASAS; HOMBRES; HOMME; Humans; LIPIDE; LIPIDOS; Lipids - blood; Lipids. Glycolipids; LIPOPROTEINAS; LIPOPROTEINE; Lipoproteins - blood; Male; Metabolisms and neurohumoral controls; REGIME ALIMENTAIRE; SANG; SANGRE; TENEUR EN LIPIDES; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Diet; Lipids; Lipoprotein; Apolipoproteins; Metabolism; Cholesterol; Feeding
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/50.3.528

A double-blind, cross-over study of the effects of adding cholesterol to the diet, equal to about two egg yolks daily, was carried out in 25 men with an average plasma cholesterol of 5.3 mmol/L. There were no significant elevations in the mean plasma concentrations of cholesterol, low-density-lipoprotein cholesterol, or apolipoprotein B. The absence of an effect was seen against two background diets, one high in saturated fatty acids and the other modified in fat content and in fatty acid composition. Although the mean high-density-lipoprotein (HDL) cholesterol concentration did not change, the proportion of HDL2 particles (radius greater than 4.4 nm) increased significantly, especially in subjects who did not show a rise in plasma cholesterol; this may represent a means of clearing dietary cholesterol. The results suggest that reducing dietary cholesterol might be emphasized for hypercholesterolemic subjects rather than for the population generally.