Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines

Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial so...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 3; p. 1368
Main Authors Serafim, Bruno, Bernardino, Ana R, Freitas, Filomena, Torres, Cristiana A V
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2023
MDPI
Subjects
Antiinfectives and antibacterials
Antiparasitic agents
Aquatic habitats
Bacteria
bioprocess
Biosynthesis
Biosynthetic Pathways
Ecosystem
Enzymes
Genes
Glycerol
Marine microorganisms
Metabolism
Metabolites
Microorganisms
phenazines
Phenazines - pharmacology
Pseudomonas
Pseudomonas - metabolism
Pseudomonas spp
Review
phenazines
bioprocess
Pseudomonas spp
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Summary:Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial sources. The most well-studied producers belong to the genus, which has been extensively investigated over the years for its ability to synthesize phenazines. This review is focused on the research performed on pseudomonads' phenazines in recent years. Their biosynthetic pathways, mechanism of regulation, production processes, bioactivities, and applications are revised in this manuscript.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28031368