Investigating neuronal activity with planar microelectrode arrays: achievements and new perspectives

• Published in: Journal of bioscience and bioengineering Vol. 100; no. 2; pp. 131 - 143
• Main Authors: Morin, Fabrice O., Takamura, Yuzuru, Tamiya, Eiichi
• Format: Journal Article
• Language: English
• Published: Amsterdarm Elsevier B.V 01.08.2005; Elsevier Science
• Subjects: Biological and medical sciences; Biotechnology; cultured neural networks; electrical stimulation; Fundamental and applied biological sciences. Psychology; long-term monitoring; Microelectrodes; Neurons - physiology; planar microelectrode arrays; Signal Transduction; synchronization; planar microelectrode arrays; electrical stimulation; synchronization; long-term monitoring; cultured neural networks; Array; Electrical stimulus; Microelectrode; Neural network; Long term; Monitoring
• ISSN: 1389-1723; 1347-4421
• DOI: 10.1263/jbb.100.131

Neuronal networks underlie memory storage and information processing in the human brain, and ultimately participate in what Eccles referred to as “the creation of consciousness”. Moreover, as physiological dysfunctions of neurons almost always translate into serious health issues, the study of the dynamics of neuronal networks has become a major avenue of research, as well as their response to pharmacological tampering. Planar microelectrode arrays represent a unique tool to investigate such dynamics and interferences, as they allow one to observe the activity of neuronal networks spread in both space and time. We will here review the major results obtained with microelectrode arrays and give an overview of the latest technological developments in the field, including our own efforts to develop the potential of this already powerful technology.