No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples

• Published in: World journal of gastroenterology : WJG Vol. 13; no. 15; pp. 2205 - 2208
• Main Authors: Magyari, Lili, Faragó, Bernadett, Bene, Judit, Horvatovich, Katalin, Lakner, Lilla, Varga, Márta, Figler, Mária, Gasztonyi, Beáta, Mózsik, Gyula, Melegh, Béla
• Format: Journal Article
• Language: English
• Published: United States Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary%Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary 21.04.2007; MTA PTE Clinical Genetics Research Group of the Hungarian Academy of Sciences at the University of Pécs, Pécs,Hungary%Markusovszky Hospital, Department of Medicine and Gastroenterology, Szombathely, Hungary%Réthy Pál Hospital, 3rd Department of Medicine and Gastroenterology, Békéscsaba, Hungary%1st Department of Medicine, School of Medicine, University of Pécs, Pécs, Hungary%Department of Gastroenterology, Zala County Hospital, Zalaegerszeg, Hungary; Baishideng Publishing Group Co., Limited
• Subjects: Adult; Antigens, CD - genetics; Antigens, CD - physiology; Antigens, Differentiation - genetics; Antigens, Differentiation - physiology; Case-Control Studies; Colitis, Ulcerative - ethnology; Colitis, Ulcerative - genetics; Colitis, Ulcerative - physiopathology; Crohn Disease - ethnology; Crohn Disease - genetics; Crohn Disease - physiopathology; CTLA-4 Antigen; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hungary; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Rapid Communication; Risk Factors; Hungary; Inflammatory bowel disease; Crohn's disease; Cytotoxic T-lymphocyte antigen 4; Ulcerative colitis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v13.i15.2205

The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohnos disease (CD) and ulcerative colitis (UC). A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test. The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.