In vitro activity of isavuconazole against clinically isolated yeasts from Chile
Isavuconazole is the last antifungal agent approved by the FDA and available for treatment of fungal infections. In the present study, the in vitro activity of isavuconazole against several yeasts was investigated. Two hundred forty-six isolates were included: 64 Candida albicans , 53 Candida paraps...
Saved in:
Published in | Brazilian journal of microbiology Vol. 51; no. 4; pp. 1801 - 1805 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
01.12.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Isavuconazole is the last antifungal agent approved by the FDA and available for treatment of fungal infections. In the present study, the in vitro activity of isavuconazole against several yeasts was investigated. Two hundred forty-six isolates were included: 64
Candida albicans
, 53
Candida parapsilosis
sensu stricto, 48
Cryptococcus neoformans
species complex, 27
C. glabrata
sensu stricto, 17
C. lusitaniae
, 17
C. tropicalis
, 5
C
.
orthopsilosis
, 4
C. krusei
, 3
C. guilliermondii
sensu stricto, 3
C. pelliculosa
, 2
C
.
dubliniensis
, 1
C
.
auris
, 1
C
.
fermentati
and 1
Trichosporon asahii
. All isolates were recovered from clinical isolates from Chile, being 221 from hemoculture, 22 from cerebrospinal fluid, 1 pleural fluid, and 1 from tissue culture. The minimal inhibitory concentrations (MICs) and minimal fungicidal concentrations (MFCs) of isavuconazole were determined. Isavuconazole demonstrated good in vitro activity against all species tested. MIC90 values and MFC ranges of isavuconazole for
Candida albicans
were 0.03 mg/L and 0.03– > 16 mg/L respectively. Non–
Candida albicans
species isolates were inhibited by ≤ 1 mg/L, with MFC ranges from < 0.03– > 16 mg/L. Also, isavuconazole was active against the non-
Candida
yeasts, being inhibited with MIC values ≤ 0.06 mg/L. Isavuconazole has exhibited potent in vitro activity against clinical isolates of
Candida
spp.,
Cryptococcus neoformans
species complex, and other clinical yeast in Chile. Despite the results obtained in the present work, additional clinical studies are necessary to verify the level of efficacy of this azole. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Responsible Editor: Rosana Puccia |
ISSN: | 1517-8382 1678-4405 |
DOI: | 10.1007/s42770-020-00333-x |