Correlation between the induction of an immediate early gene, zif/268, and long-term potentiation in the dentate gyrus

Expression of the immediate early gene zif/268 (also termed NGFI-A, Krox 24, TIS8 and Egr-1) was investigated in awake rats following various long-term potentiation (LTP) induction protocols. zif/268 mRNA (Northern blots) and protein (immunohistochemistry) levels sharply increased following LTP, and...

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Bibliographic Details
Published inBrain research Vol. 580; no. 1-2; p. 147
Main Authors Richardson, C L, Tate, W P, Mason, S E, Lawlor, P A, Dragunow, M, Abraham, W C
Format Journal Article
LanguageEnglish
Published Netherlands 15.05.1992
Subjects
Animals
Base Sequence
Blotting, Northern
Evoked Potentials - physiology
Gene Expression - physiology
Hippocampus - physiology
Immunohistochemistry
Male
Molecular Sequence Data
Nerve Tissue Proteins - genetics
Oligonucleotide Probes
Rats
Rats, Inbred Strains
RNA, Messenger - biosynthesis
Time Factors
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Summary:Expression of the immediate early gene zif/268 (also termed NGFI-A, Krox 24, TIS8 and Egr-1) was investigated in awake rats following various long-term potentiation (LTP) induction protocols. zif/268 mRNA (Northern blots) and protein (immunohistochemistry) levels sharply increased following LTP, and followed a time course characteristic of other immediate early genes. When measured across 3 tetanization protocols known to produce differing degrees of LTP persistence, zif/268 induction was found to be more highly correlated with LTP duration than with the magnitude of initial LTP. These data support the hypothesis that the immediate early gene zif/268 plays a role as a third messenger in the cascade of cellular and nuclear events that govern the persistence of LTP.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(92)90938-6