The dipeptidyl peptidase IV inhibitor NVP-DPP728 reduces plasma glucagon concentration in cats

• Published in: The veterinary journal (1997) Vol. 183; no. 3; pp. 355 - 357
• Main Authors: Furrer, Daniela, Kaufmann, Karin, Tschuor, Flurin, Reusch, Claudia E., Lutz, Thomas A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2010
• Subjects: animal diseases; animal models; Animals; Cat; cat diseases; Cats; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Dipeptidyl peptidase IV; Dipeptidyl-Peptidase IV Inhibitors - pharmacology; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; Disease Models, Animal; Glucagon; Glucagon - blood; Glucagon-Like Peptide 1 - pharmacology; Glucagon-Like Peptide 1 - therapeutic use; Glucagon-like peptide-1; glucagon-like peptides; glucose tolerance; Humans; insulin; Insulin - metabolism; Insulin Secretion; Male; Nitriles; postprandial state; Pyrrolidines; Glucagon-like peptide-1; Dipeptidyl peptidase IV; Glucagon; Diabetes mellitus; Cat
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2008.11.017

Glucagon-like peptide-1 (GLP-1) analogues and inhibitors of its degrading enzyme, dipeptidyl peptidase IV (DPPIV), are interesting therapy options in human diabetics because they increase insulin secretion and reduce postprandial glucagon secretion. Given the similar pathophysiology of human type 2 and feline diabetes mellitus, this study investigated whether the DPPIV inhibitor NVP-DPP728 reduces plasma glucagon levels in cats. Intravenous glucose tolerance tests (ivGTT; 0.5 g/kg glucose after 12 h fasting) and a meal response test (test meal of 50% of average daily food intake, offered after 24 h fasting) were performed in healthy experimental cats. NVP-DPP728 (0.5–2.5 mg/kg IV or SC) significantly reduced glucagon output in all tests and increased insulin output in the ivGTT. Follow-up studies will investigate the potential usefulness as therapy in diabetic cats.