Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature

Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse. We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections. This case illustrates the benefit...

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Published inGynecologic oncology Vol. 96; no. 1; pp. 235 - 240
Main Authors Crew, Katherine D., Cohen, Michael H., Smith, Daniel H., Tiersten, Amy D., Feirt, Nikki M., Hershman, Dawn L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2005
Subjects
Cytoreductive surgery
Female
Granulosa cell tumor
Granulosa Cell Tumor - blood
Granulosa Cell Tumor - pathology
Granulosa Cell Tumor - secondary
Granulosa Cell Tumor - surgery
Humans
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Middle Aged
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Ovarian Neoplasms - blood
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Ovary
Ovary
Cytoreductive surgery
Granulosa cell tumor
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Summary:Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse. We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections. This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2004.09.023