Tactile stimulation partially prevents neurodevelopmental changes in visual tract caused by early iron deficiency

• Published in: Brain research Vol. 1657; pp. 130 - 139
• Main Authors: Horiquini-Barbosa, Everton, Gibb, Robbin, Kolb, Bryan, Bray, Douglas, Lachat, Joao-Jose
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.02.2017
• Subjects: Animals; Animals, Newborn; Astrocyte; Astrocytes - metabolism; Astrocytes - pathology; Body Weight; Diet; Disease Models, Animal; Handling (Psychology); Iron - deficiency; Male; Musculoskeletal Manipulations; Myelinated fibers; Neonatal handling; Nerve Fibers, Myelinated - metabolism; Nerve Fibers, Myelinated - pathology; Neurodevelopment; Neurology; Neuroprotection; Oligodendrocyte; Oligodendroglia - metabolism; Oligodendroglia - pathology; Optic nerve; Optic Nerve - blood supply; Optic Nerve - growth & development; Optic Nerve - metabolism; Optic Nerve - pathology; Physical Stimulation; Random Allocation; Rats, Wistar; Tactile stimulation; Visual Pathways - blood supply; Visual Pathways - growth & development; Visual Pathways - metabolism; Visual Pathways - pathology; Neonatal handling; Optic nerve; Myelinated fibers; Oligodendrocyte; Neurodevelopment; Tactile stimulation; Astrocyte
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2016.12.003

Highlights • Early exposure to iron deficient diet altered cellular components of optic nerve in developing rats. • Tactile stimulation dramatically reversed iron deficiency-induced changes in neuroanatomy. • Tactile stimulation early in life acts as a powerful neuroanatomical reorganization tool.