2-Phenethylamines in Medicinal Chemistry: A Review

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 2; p. 855
• Main Authors: Nieto, Carlos T, Manchado, Alejandro, Belda, Leland, Diez, David, Garrido, Narciso M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.01.2023; MDPI
• Subjects: 2-phenethylamine; Adenosine; Adrenergic receptors; adrenoceptors; Amphetamines; Antidepressants; carbonyl anhydrase; Catecholamines; Chemistry; Chemistry, Pharmaceutical; Cocaine; Dopamine; dopamine receptor; HIV; Human immunodeficiency virus; Hypertension; Inflammation; Ligands; medicinal chemistry; Pharmaceutical sciences; Phenethylamines - chemistry; Phenethylamines - pharmacology; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Review; Therapeutic targets; sigma receptors; ligands; PPAR; DAT; MAO; adrenoceptors; 5-HT; carbonyl anhydrase; TAAR1; 2-phenethylamine; dopamine receptor; medicinal chemistry
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28020855

A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.