Role of oxidative stress in epileptogenesis and potential implications for therapy

• Published in: Pharmacological reports Vol. 72; no. 5; pp. 1218 - 1226
• Main Authors: Borowicz-Reutt, Kinga K., Czuczwar, Stanisław J.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2020
• Subjects: Drug Safety and Pharmacovigilance; Medicine; Pharmacotherapy; Pharmacy; Review; Oxidative stress; Epileptogenesis; Free radicals; Oxygen species; Nitrogen species

In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of “redox messengers”. In a state of oxidative stress, they trigger a cascade of events leading to epileptogenesis. During this latent, free of seizures period, a cascade of neurological changes takes pl...