Role of oxidative stress in epileptogenesis and potential implications for therapy

In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of “redox messengers”. In a state of oxidative stress, they trigger a cascade of events leading to epileptogenesis. During this latent, free of seizures period, a cascade of neurological changes takes pl...

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Bibliographic Details
Published inPharmacological reports Vol. 72; no. 5; pp. 1218 - 1226
Main Authors Borowicz-Reutt, Kinga K., Czuczwar, Stanisław J.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.10.2020
Subjects
Drug Safety and Pharmacovigilance
Medicine
Pharmacotherapy
Pharmacy
Review
Oxidative stress
Epileptogenesis
Free radicals
Oxygen species
Nitrogen species
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Summary:In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of “redox messengers”. In a state of oxidative stress, they trigger a cascade of events leading to epileptogenesis. During this latent, free of seizures period, a cascade of neurological changes takes place and finally leads to spontaneous recurrent seizures. The main processes involved in seizure generation are: neuroinflammation, neurodegeneration with anomalous neuroregeneration and lowering seizure threshold. Time of epileptogenesis offers a unique therapeutic window to prevent or at least attenuate seizure development. Animal data indicate that some antioxidants (for instance, resveratrol) may bear an anti-epileptogenic potential.
Bibliography:ObjectType-Article-2
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ISSN:1734-1140
2299-5684
DOI:10.1007/s43440-020-00143-w