The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury

Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neut...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 78; no. 1; p. 310
Main Authors Thiagarajan, R R, Winn, R K, Harlan, J M
Format Journal Article
LanguageEnglish
Published Germany 1997
Subjects
Animals
Cell Adhesion Molecules - physiology
Endothelium, Vascular - physiology
Humans
Immunoglobulins - physiology
Integrins - physiology
Leukocytes - physiology
Neutrophils - physiology
Reperfusion Injury - blood
Reperfusion Injury - physiopathology
Selectins - physiology
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Summary:Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.
ISSN:0340-6245
DOI:10.1055/s-0038-1657545