Evidence for the occurrence of a fast-acting inhibitor for tissue-type plasminogen activator in human plasma

Human plasma contains a fast-acting t-PA inhibitor, which is not identical with alpha 2-antiplasmin or alpha 2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurri...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 51; no. 3; p. 392
Main Authors Verheijen, J H, Chang, G T, Kluft, C
Format Journal Article
LanguageEnglish
Published Germany 01.01.1984
Subjects
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Glycoproteins - isolation & purification
Humans
Iodine Radioisotopes
Kinetics
Molecular Weight
Plasminogen Activators - antagonists & inhibitors
Plasminogen Inactivators
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Summary:Human plasma contains a fast-acting t-PA inhibitor, which is not identical with alpha 2-antiplasmin or alpha 2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear.
ISSN:0340-6245
DOI:10.1055/s-0038-1661109