The potential roles of nm23 in cancer metastasis and cellular differentiation
The majority of cancer patients succumb to the consequences of metastatic disease. A correlation of increased nm23 expression to low metastatic potential has been established in several malignancies, based on published prognostic studies with tumour cohorts and transfection studies. Transfection of...
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Published in | European journal of cancer (1990) Vol. 31; no. 7; pp. 1096 - 1100 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.07.1995
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Subjects | |
Online Access | Get full text |
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Summary: | The majority of cancer patients succumb to the consequences of metastatic disease. A correlation of increased
nm23 expression to low metastatic potential has been established in several malignancies, based on published prognostic studies with tumour cohorts and transfection studies. Transfection of highly metastatic MDA-MB-435 human breast carcinoma cells with
nm23-H1 cDNA resulted in a significant reduction in the metastatic potential
in vivo. These transfections also showed inhibition of colonisation and motility, as well as morphological and biosynthetic differentiation
in vitro. The biochemical mechanism of Nm23-H1 action, as well as the identity of proteins involved in its functional biochemical pathway, are still unknown. We summarise published and recent research concerning the role of the
nm23 gene in metastasis and normal cellular differentiation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0959-8049 1879-0852 |
DOI: | 10.1016/0959-8049(95)00152-9 |