Homocysteine and schizophrenia: From prenatal to adult life

Homocysteine is becoming increasingly recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia. In this review, we first present background information supporting a role for homocysteine in schizophrenia. We then discuss our work on the role of hyperhomocystinemi...

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Published inProgress in neuro-psychopharmacology & biological psychiatry Vol. 29; no. 7; pp. 1175 - 1180
Main Authors Brown, Alan S., Susser, Ezra S.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.09.2005
Subjects
Female
Homocysteine
Homocystine - metabolism
Humans
Male
Parents
Pregnancy
Prenatal Exposure Delayed Effects
Risk
Schizophrenia
Schizophrenia - metabolism
Schizophrenic Psychology
KPMCP
NMDA
Schizophrenia
CNS
MTHFR
ICD
Homocysteine
HPLC
PDS
NTD
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Summary:Homocysteine is becoming increasingly recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia. In this review, we first present background information supporting a role for homocysteine in schizophrenia. We then discuss our work on the role of hyperhomocystinemia during adulthood and risk of schizophrenia, and present preliminary evidence on a potential relationship between prenatal homocysteine and schizophrenia. Finally, we discuss the implications of these findings for future work on nutritional etiologies of schizophrenia.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2005.06.028