DSPECT-specific normative limits for left ventricular size and function

• Published in: Journal of nuclear cardiology Vol. 29; no. 6; pp. 3293 - 3299
• Main Authors: Ibrahim, Joseph, Nieves, Ricardo A., Barakat, Amr F., Hynal, Kevin, Shpilsky, Daniel, Soman, Prem
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.12.2022; Springer International Publishing; Springer Nature B.V
• Subjects: Adult; Aged; Cardiology; Cardiovascular disease; Coronary Artery Disease - diagnostic imaging; Female; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; MPI; Myocardial Perfusion Imaging; Nuclear Medicine; Original Article; Radiology; Radiopharmaceuticals; SPECT; Technetium Tc 99m Sestamibi; Tests; Tomography, Emission-Computed, Single-Photon - methods; Ventricular Function, Left; Women; Tc-99m; LVEDVi; MPI; LVESVi; gSPECT; LVEF; LVESV; ASPECT; LVEDV; SPECT; Tests
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1007/s12350-022-02932-7

Differences in spatial resolution and image filtering between the solid-state DSPECT and traditional Anger SPECT (ASPECT) cameras are likely to result in differences in LV measurements. However, DSPECT-specific normal values are not available. The traditional approach of using patients deemed to have a low (< 5%) probability of coronary artery disease for the derivation of normative values has a number of limitations. We used healthy organ-donor subjects without known disease or medication use for derivation of normal values. Subjects were 92 consecutive kidney or liver donors who underwent single-day rest (5 mCi)-stress (15 mCi) Tc-99m sestamibi-gated SPECT myocardial perfusion imaging (MPI) on the DSPECT camera for pre-operative evaluation and had normal perfusion and LV function. Exclusion criteria included any known cardiac disease or medications. LV measurements were made on the post-stress supine stress images using QGS®. Of 92 subjects (mean age 54.4 ± 15.0 and 39% men), mean EF ± 2SD for women and men was 77.2% ± 14.1% and 70.0 % ± 14.7%, respectively. Mean end-diastolic volume ± 2SD for women and men was 67.0 ± 32.2 mL and 99.6 ± 51.6 mL (indexed 38.3 ± 17.2 mL/m2 and 48.1 ± 25.9 mL/m2), respectively. Mean end-systolic volume ± 2SD for women and men was 16.1 ± 15.7 mL and 31.2 ± 29.2 mL (indexed 9.2 ± 8.8 mL/m2 and 15.0 ± 14.2 mL/m2), respectively. Mean LV wall volume ± 2SD for women and men was 95.9 ± 26.0 mL and 112.0 ± 48.8 mL (indexed 55.0 ± 13.8 mL/m2 and 54.1 ± 24.6 mL/m2), respectively. We report DSPECT-specific LV measurements from normal subjects from which limits of normality can be derived for clinic use. Organ donors who undergo pre-operative MPI are a suitable cohort for the derivation of normal values.