Coronary artery disease in young patients: Arteriographic and clinical review of 40 cases aged 35 and under

• Published in: The American heart journal Vol. 87; no. 6; pp. 689 - 696
• Main Authors: Davia, James E., Hallal, F.Joseph, Cheitlin, Melvin D., Gregoratos, Gabriel, McCarty, Richard, Foote, William
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.1974
• Subjects: Adult; Age Factors; Angina Pectoris - etiology; Blood Glucose; Blood Pressure; Blood Proteins; Coronary Angiography; Coronary Disease - blood; Coronary Disease - diagnosis; Coronary Disease - diagnostic imaging; Coronary Disease - genetics; Electrocardiography; Female; Humans; Lipoproteins - blood; Male; Myocardial Infarction - complications; Obesity - complications; Smoking
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/0002-8703(74)90412-8

Coronary arteriography was performed in 60 patients aged 35 or less with suggested coronary artery disease (CAD). Twenty patients (Group 1) had normal coronary arteries and 40 patients (Group 2) had one or more obstructive lesions. The left anterior descending artery was commonly involved followed by the right coronary and left circumflex arteries. The right coronary artery was most commonly completely obstructed. Single-vessel disease (50 per cent or greater obstruction) was found in 60 per cent of the patients, an incidence that is considerably higher than in studies of older patients. A total of 1.6 diseased vessels per patient was present. A hyperlipoproteinemia (HLP) was found in 68 per cent of Group 2 patients. Patients in Group 2 with an HLP had significantly more CAD than Group 2 patients with normal lipoproteins. The incidence of the following clinical features were not significantly different in Groups 1 and 2: typical angina, atypical angina, positive family history, smoking, hypertension, obesity, abnormal electrocardiogram, positive treadmill test, HLP, and diabetes mellitus. A fourth heart sound and a history of a myocardial infarction were significantly common in Group 2. Since almost all of the previously reported cases of myocardial infarction with normal coronary arteries have occurred in young patients, history of a myocardial infarction does not assure the presence of obstructive coronary artery lesions. It is suggested that coronary arteriography is a justifiable procedure in a young patient who presents with a clinical picture that is either compatible with or cannot be clearly distinguished from CAD.