Roles of long non-coding RNAs in gastric cancer metastasis

Gastric cancer is the second leading cause of cancer- related deaths. Metastasis, which is an importantelement of gastric cancer, leads to a high mortality rateand to a poor prognosis. Gastric cancer metastasis hasa complex progression that involves multiple biologicalprocesses. The comprehensive me...

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Published inWorld journal of gastroenterology : WJG Vol. 21; no. 17; pp. 5220 - 5230
Main Authors Yang, Zi-Guo, Gao, Ling, Guo, Xiao-Bo, Shi, Yu-Long
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 07.05.2015
Subjects
Animals
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
cancer;Metastasis
Cell Movement
Development
Function
Gastric
Gene Expression Regulation, Neoplastic
Humans
Long
Neoplasm Invasiveness
non-coding
Review
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNAs
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Development
Function
Long non-coding RNAs
Metastasis
Gastric cancer
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Summary:Gastric cancer is the second leading cause of cancer- related deaths. Metastasis, which is an importantelement of gastric cancer, leads to a high mortality rateand to a poor prognosis. Gastric cancer metastasis hasa complex progression that involves multiple biologicalprocesses. The comprehensive mechanisms of metastasisremain unclear, though traditional regulation modulatesthe molecular functions associated with metastasis.Long non-coding RNAs （lncRNAs） have a role in differentgene regulatory pathways by epigenetic modificationand by transcriptional and post-transcription regulation.lncRNAs participate in various diseases, includingAlzheimer＇s disease, cardiovascular disease, and cancer.The altered expressions of certain lncRNAs are linked togastric cancer metastasis and invasion, as with tumorsuppressor genes or oncogenes. Studies have partlyelucidated the roles of lncRNAs as biomarkers and intherapies, as well as their gene regulatory mechanisms.However, comprehensive knowledge regarding thefunctional mechanisms of gene regulation in metastaticgastric cancer remains scarce. To provide a theoreticalbasis for therapeutic intervention in metastatic gastriccancer, we reviewed the functions of lncRNAs and theirregulatory roles in gastric cancer metastasis.
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Telephone: +86-531-68777198 Fax: +86-531-68776200
Author contributions: Yang ZG and Guo XB wrote the paper; Gao L provided financial support; Gao L, Guo XB and Shi YL reviewed and edited the manuscript.
Correspondence to: Xiao-Bo Guo, Associated professor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. xiaoboguo@hotmail.com
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i17.5220