Sonodynamically induced anti-tumor effect with protoporphyrin IX on hepatoma-22 solid tumor

• Published in: Ultrasonics Vol. 51; no. 5; pp. 539 - 546
• Main Authors: Wang, Xiaobing, Wang, Yu, Wang, Pan, Cheng, Xiaoxia, Liu, Quanhong
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2011; Elsevier
• Subjects: Animals; Anti-oxidative enzymes; Anti-tumor effect; Antineoplastic Agents - therapeutic use; Biocompatibility; Biological and medical sciences; Biomedical materials; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell Line, Tumor; Enzymes; H-22 solid tumor; In vivo testing; In vivo tests; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Medical sciences; Mice; Mice, Inbred ICR; Protoporphyrin IX; Protoporphyrins - therapeutic use; Radiation-Sensitizing Agents - therapeutic use; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Sonodynamic therapy; Surgical implants; Technology. Biomaterials. Equipments. Material. Instrumentation; Therapy; Treatment Outcome; Treatment. General aspects; Tumors; Ultrasonic Therapy - methods; H-22 solid tumor; Anti-tumor effect; Protoporphyrin IX; Sonodynamic therapy; Anti-oxidative enzymes; Therapy; Acoustic treatment; Rodentia; Ultrasonic treatment; Temperature effect; Hepatocellular carcinoma; Cytotoxicity; Synergism; Vertebrata; Mammalia; Transmission electron microscopy; Protoporphyrin; Mouse; Muscle; Skin; Biological effect; Pharmacokinetics; Damaging

► Protoporphyrin IX in H-22 tumors was relatively higher at 8–36 h after administration. ► Three times treatment inhibited 59.89% tumor growth and 45.86% tumor weight. ► The mice had a good vigor without so much weight change by SDT treatment. ► Obvious tissue destruction and decreased anti-oxidativ...