Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Abstract Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from human...

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Published inCardiovascular research Vol. 117; no. 1; pp. 43 - 59
Main Authors Zacchigna, Serena, Paldino, Alessia, Falcão-Pires, Inês, Daskalopoulos, Evangelos P, Dal Ferro, Matteo, Vodret, Simone, Lesizza, Pierluigi, Cannatà, Antonio, Miranda-Silva, Daniela, Lourenço, André P, Pinamonti, Bruno, Sinagra, Gianfranco, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Kehat, Izhak, Tocchetti, Carlo G, Russo, Michele, Ghigo, Alessandra, Cimino, James, Hirsch, Emilio, Dawson, Dana, Ciccarelli, Michele, Oliveti, Marco, Linke, Wolfgang A, Cuijpers, Ilona, Heymans, Stephane, Hamdani, Nazha, de Boer, Martine, Duncker, Dirk J, Kuster, Diederik, van der Velden, Jolanda, Beauloye, Christophe, Bertrand, Luc, Mayr, Manuel, Giacca, Mauro, Leuschner, Florian, Backs, Johannes, Thum, Thomas
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2021
Subjects
Diastolic function
Animal models
Echocardiography
Systolic function
Standardization
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Summary:Abstract Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions. Graphical Abstract
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvaa110